Experimental Studies of the Nasopharyngeal Secretions from Influenza Patients
نویسندگان
چکیده
Cultivation of Bacterium pneumosintes in the collodion sac dialysate of a tissue medium produces an antigen suitable for serological tests. Injection of dialysate cultures of Bacterium pneumosintes into rabbits results in the production of antibodies demonstrable by agglutination, precipitation, complement fixation, and phagocytic reactions. Four strains of Bacterium pneumosintes, three from the first epidemic influenzal wave (1918-19) and one from the second (1920), show identical antigenic characters. The blood serum of rabbits experimentally injected with the glycerolated active material of rabbit passages contains specific agglutinins for Bacterium pneumosintes, whereas normal rabbit serum does not.
منابع مشابه
EXPERIMENTAL STUDIES OF THE NASOPHARYNGEAL SECRETIONS FROM INFLUENZA PATIENTS. II. FILTERABILITY AND RESISTANCE TO GLYCEROL. BY PETER K. OLITSKY, M.D., ANn
In our first communication 1 we described the particular effects induced in rabbits by the nasopharyngeal secretions from cases of uncomplicated influenza. We now propose to define more exactly the nature of the peculiar or active substance responsible for these effects and to distinguish it from bacteria of the ordinary species. Before presenting what are regarded as the decisive experiments, ...
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In earlier papers of this series we have reported the observation of specific antibodies against Bacterium pneumosintes in the blood serum of experimentally infected rabbits. Thus, specific agglutinins were detected after the intratracheal injection of the active agent of the nasopharyngeal secretions of influenza patients, after the intratracheal or intravenous injection of living cultures of ...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 33 شماره
صفحات -
تاریخ انتشار 2003